Bishop Lab Website
People
The lab is under the direction of Dr. Doug Bishop, who joined the University in 1993. He has served as principal investigator for several research projects, including many receiving funding from the US Army and the National Science Foundation.
The Bishop Lab also collaborates with Dr. Phil Connell, a graduate of the department's radiation oncology residency program. Clinically, Dr. Connell focuses on sarcomas and mediastinal tumors, but he also remains active in cancer biology research.
Dr. Bishop supervises several other members of the lab, including research associates, technicians, postdoctoral scholars and students.
Douglas K. Bishop, PhD
Professor of Radiation and Cellular Oncology
Professor of Molecular Genetics and Cell Biology
Committee on Genetics, Genomics and Systems Biology
Philip P. Connell, MD
Professor of Radiation and Cellular Oncology
Research
The Bishop lab studies the mechanism of homologous repair, emphasizing the recombination proteins Dmc1 and Rad51 that are related to the bacterial repair protein RecA. The investigation considers how Dmc1's function is specialized for meiosis, how the functions of Rad51 and Dmc1 differ, and how these proteins interact.
Recent Publications
- Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.Nucleic Acids Res. 2012 May 9.
- Shah PP, Zheng X, Epshtein A, Carey JN, Bishop DK, Klein HL. Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth. Mol Cell. 2010 Sep 24;39(6):862-72.
- Ferrari SR, Grubb J, Bishop DK. The Mei5-Sae3 protein complex mediates Dmc1 activity in Saccharomyces cerevisiae. J Biol Chem. 2009 May 1;284(18):11766-70. Epub 2009 Mar 7.
- Jayathilaka K, Sheridan SD, Bold TD, Bochenska K, Logan HL, Weichselbaum RR, Bishop DK, Connell PP. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15848-53.
- Sheridan SD, Yu X, Roth R, Heuser JE, Sehorn MG, Sung P, Egelman EH, Bishop DK. A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments. Nucleic Acids Res. 2008 Jul;36(12):4057-66. Epub 2008 Jun 4.